Confirmed case of Zika virus congenital infection, Spain, March 2016

Euro Surveill. 2016 Jun 16;21(24). doi: 10.2807/1560-7917.ES.2016.21.24.30261.


We describe Zika virus (ZIKV) vertical transmission in an imported case in Spain, in a 17-week pregnant woman. ZIKV IgG, IgM and RNA were detected in serum in week 17. At 19 weeks, ultrasound scan revealed fetal malformations and ZIKV was detected in the amniotic fluid. Pregnancy was terminated at week 21; autopsy of the fetus revealed bilateral hydrocephalus, brain microcalcifications and arthrogryposis multiplex congenita. ZIKV was detected in the umbilical cord and brain tissue.

Keywords: Flaviviridae; Zika virus; imported viral diseases; pregnancy; sexually transmitted infections; surveillance; vector-borne infections.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple / diagnosis
  • Abnormalities, Multiple / virology*
  • Abortion, Induced
  • Amniotic Fluid / virology*
  • Arthrogryposis / diagnostic imaging
  • Arthrogryposis / virology*
  • Diagnosis, Differential
  • Female
  • Humans
  • Pregnancy
  • Prenatal Diagnosis / methods
  • Spain
  • Young Adult
  • Zika Virus Infection / congenital*
  • Zika Virus Infection / diagnosis*
  • Zika Virus Infection / virology*