Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture)

Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8502-27. doi: 10.1002/anie.201601524. Epub 2016 Jun 23.


Ultraviolet light damages DNA by converting two adjacent thymines into a thymine dimer which is potentially mutagenic, carcinogenic, or lethal to the organism. This damage is repaired by photolyase and the nucleotide excision repair system in E. coli by nucleotide excision repair in humans. The work leading to these results is presented by Aziz Sancar in his Nobel Lecture.

Keywords: Maxicell method; circadian clock; cryptochrome; nucleotide excision repair; photoreactivation.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases / metabolism*
  • Cryptochromes / metabolism
  • DNA Repair*
  • Deoxyribodipyrimidine Photo-Lyase / chemistry
  • Deoxyribodipyrimidine Photo-Lyase / genetics
  • Deoxyribodipyrimidine Photo-Lyase / metabolism*
  • Deoxyribonucleases / metabolism*
  • Escherichia coli / enzymology
  • Escherichia coli / metabolism
  • Humans
  • Polymorphism, Single Nucleotide
  • Pyrimidine Dimers / chemistry
  • Pyrimidine Dimers / metabolism
  • Ultraviolet Rays


  • Cryptochromes
  • Pyrimidine Dimers
  • Deoxyribonucleases
  • Adenosine Triphosphatases
  • Deoxyribodipyrimidine Photo-Lyase