Protein Encoded by v-erbA Functions as a Thyroid-Hormone Receptor Antagonist

Nature. 1989 Jun 22;339(6226):593-7. doi: 10.1038/339593a0.

Abstract

The thyroid-hormone receptor can, in the absence of its ligand, suppress activity of a responsive promoter. Addition of thyroid hormone, however, results in the stimulation of expression. The oncogenic derivative of the thyroid-hormone receptor, v-erbA, acts as a constitutive repressor and, when coexpressed with the receptor, blocks activation by thyroid hormone. Thus, v-erbA may be the first example of a dominant negative oncogene.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Avian Myeloblastosis Virus / genetics
  • Carrier Proteins / antagonists & inhibitors
  • Carrier Proteins / genetics*
  • Cell Line
  • Chlorocebus aethiops
  • DNA / metabolism
  • Gene Expression Regulation*
  • Genetic Vectors
  • Membrane Proteins / antagonists & inhibitors
  • Membrane Proteins / genetics*
  • Mutation
  • Oncogenes*
  • Repressor Proteins / genetics
  • Thyroid Hormones*
  • Transfection

Substances

  • Carrier Proteins
  • Membrane Proteins
  • Repressor Proteins
  • Thyroid Hormones
  • thyroid hormone-binding proteins
  • DNA