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. 2016 Sep;24(9):684-686.
doi: 10.1016/j.tim.2016.05.008. Epub 2016 Jun 20.

Feverish Quest for Ebola Immunotherapy: Straight or Cocktail?

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Feverish Quest for Ebola Immunotherapy: Straight or Cocktail?

Erica Ollmann Saphire et al. Trends Microbiol. .

Abstract

The ebolavirus immunotherapeutics field has replaced previous perceptions of antibody inadequacy with a new abundance of monoclonals exhibiting post exposure efficacy. Now the questions are: what epitopes to target, what immunological mechanisms to seek, whether species-specific or broadly reactive antibodies are best, and whether a cocktail or monotherapy should be used.

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