Abstract
A series of C₂-symmetric chiral benzimidazolium salts, the precursor of N-heterocyclic carbene ligands, were designed and synthesized from 1,2-dibromobenzene. In situ prepared corresponding carbenes were tested in the asymmetric palladium-catalyzed intramolecular α-arylation of amides, affording chiral diarylmethanols with high yields and moderate enantioselectivities.
Keywords:
N-heterocyclic carbene; Pd-catalyzed; asymmetric intramolecular α-arylation; benzimidazolium.
MeSH terms
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Amides / chemical synthesis
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Amides / chemistry*
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Anesthetics, Local / chemical synthesis
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Anesthetics, Local / chemistry*
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Bromobenzenes / chemical synthesis
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Bromobenzenes / chemistry*
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Catalysis
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Indoles / chemical synthesis
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Indoles / chemistry*
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Methane / analogs & derivatives
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Methane / chemistry
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Palladium / chemistry
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Salts / chemistry
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Stereoisomerism
Substances
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Amides
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Anesthetics, Local
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Bromobenzenes
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Indoles
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Salts
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carbene
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1,2-dibromobenzene
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Palladium
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Methane