Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016

doi:10.1007/s00277-016-2711-1

. 2016 Sep;95(9):1435-55.

doi: 10.1007/s00277-016-2711-1. Epub 2016 Jun 24.

Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016

Andrew J Ullmann¹, Martin Schmidt-Hieber², Hartmut Bertz³, Werner J Heinz⁴, Michael Kiehl⁵, William Krüger⁶, Sabine Mousset⁷, Stefan Neuburger⁸, Silke Neumann⁹, Olaf Penack¹⁰, Gerda Silling¹¹, Jörg Janne Vehreschild¹², Hermann Einsele⁴, Georg Maschmeyer¹³; Infectious Diseases Working Party of the German Society for Hematology and Medical Oncology (AGIHO/DGHO) and the DAG-KBT (German Working Group for Blood and Marrow Transplantation)

Affiliations

¹ Department of Internal Medicine II, Division of Hematology and Oncology, Division of Infectious Diseases, Universitätsklinikum, Julius Maximilian's University, Oberdürrbacher Str. 6, 97080, Würzburg, Germany. andrew.ullmann@uni-wuerzburg.de.
² Clinic for Hematology, Oncology und Tumor Immunology, Helios Clinic Berlin-Buch, Berlin, Germany.
³ Department of Hematology/Oncology, University of Freiburg Medical Center, 79106, Freiburg, Germany.
⁴ Department of Internal Medicine II, Division of Hematology and Oncology, Division of Infectious Diseases, Universitätsklinikum, Julius Maximilian's University, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
⁵ Medical Clinic I, Klinikum Frankfurt (Oder), Frankfurt (Oder), Germany.
⁶ Haematology and Oncology, Stem Cell Transplantation, Palliative Care, University Hospital Greifswald, Greifswald, Germany.
⁷ Medizinische Klinik III, Palliativmedizin und interdisziplinäre Onkologie, St. Josefs-Hospital Wiesbaden, Wiesbaden, Germany.
⁸ Sindelfingen-Böblingen Clinical Centre, Medical Department I, Division of Hematology and Oncology, Klinikverbund Südwest, Sindelfingen, Germany.
⁹ Medical Oncology, AMO MVZ, Wolfsburg, Germany.
¹⁰ Hematology, Oncology and Tumorimmunology, Charité University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany.
¹¹ Department of Internal Medicine IV, University Hospital RWTH Aachen, Aachen, Germany.
¹² Department I of Internal Medicine, German Centre for Infection Research, Partner-site: Bonn-Cologne, University Hospital of Cologne, Cologne, Germany.
¹³ Department of Hematology, Oncology and Palliative Care, Klinikum Ernst von Bergmann, Potsdam, Germany.

PMID: 27339055
PMCID: PMC4972852
DOI: 10.1007/s00277-016-2711-1

Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016

Andrew J Ullmann et al. Ann Hematol. 2016 Sep.

. 2016 Sep;95(9):1435-55.

doi: 10.1007/s00277-016-2711-1. Epub 2016 Jun 24.

Authors

Affiliations

¹ Department of Internal Medicine II, Division of Hematology and Oncology, Division of Infectious Diseases, Universitätsklinikum, Julius Maximilian's University, Oberdürrbacher Str. 6, 97080, Würzburg, Germany. andrew.ullmann@uni-wuerzburg.de.
² Clinic for Hematology, Oncology und Tumor Immunology, Helios Clinic Berlin-Buch, Berlin, Germany.
³ Department of Hematology/Oncology, University of Freiburg Medical Center, 79106, Freiburg, Germany.
⁴ Department of Internal Medicine II, Division of Hematology and Oncology, Division of Infectious Diseases, Universitätsklinikum, Julius Maximilian's University, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
⁵ Medical Clinic I, Klinikum Frankfurt (Oder), Frankfurt (Oder), Germany.
⁶ Haematology and Oncology, Stem Cell Transplantation, Palliative Care, University Hospital Greifswald, Greifswald, Germany.
⁷ Medizinische Klinik III, Palliativmedizin und interdisziplinäre Onkologie, St. Josefs-Hospital Wiesbaden, Wiesbaden, Germany.
⁸ Sindelfingen-Böblingen Clinical Centre, Medical Department I, Division of Hematology and Oncology, Klinikverbund Südwest, Sindelfingen, Germany.
⁹ Medical Oncology, AMO MVZ, Wolfsburg, Germany.
¹⁰ Hematology, Oncology and Tumorimmunology, Charité University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany.
¹¹ Department of Internal Medicine IV, University Hospital RWTH Aachen, Aachen, Germany.
¹² Department I of Internal Medicine, German Centre for Infection Research, Partner-site: Bonn-Cologne, University Hospital of Cologne, Cologne, Germany.
¹³ Department of Hematology, Oncology and Palliative Care, Klinikum Ernst von Bergmann, Potsdam, Germany.

PMID: 27339055
PMCID: PMC4972852
DOI: 10.1007/s00277-016-2711-1

Abstract

Infectious complications after allogeneic haematopoietic stem cell transplantation (allo-HCT) remain a clinical challenge. This is a guideline provided by the AGIHO (Infectious Diseases Working Group) of the DGHO (German Society for Hematology and Medical Oncology). A core group of experts prepared a preliminary guideline, which was discussed, reviewed, and approved by the entire working group. The guideline provides clinical recommendations for the preventive management including prophylactic treatment of viral, bacterial, parasitic, and fungal diseases. The guideline focuses on antimicrobial agents but includes recommendations on the use of vaccinations. This is the updated version of the AGHIO guideline in the field of allogeneic haematopoietic stem cell transplantation utilizing methods according to evidence-based medicine criteria.

Keywords: Bacteria; Fungal; Infections; Viral.

PubMed Disclaimer

Comment in

Vaccination of allogeneic hematopoietic stem cell transplant recipients-what should be considered?
Hilgendorf I, Greinix H, Halter J, Lawitschka A, Wolff D. Hilgendorf I, et al. Ann Hematol. 2017 Apr;96(4):701-702. doi: 10.1007/s00277-017-2922-0. Epub 2017 Jan 17. Ann Hematol. 2017. PMID: 28097373 No abstract available.

Cited by

Long-term outcome of 2-year survivors after allogeneic hematopoietic cell transplantation for acute leukemia.
Larue M, Labopin M, Schroeder T, Huang XJ, Blau IW, Schetelig J, Ganser A, Hamladji RM, Bethge W, Kröger N, Socié G, Salmenniemi U, Sengeloev H, Dholaria B, Savani BN, Nagler A, Ciceri F, Mohty M. Larue M, et al. Hemasphere. 2024 Oct 22;8(10):e70026. doi: 10.1002/hem3.70026. eCollection 2024 Oct. Hemasphere. 2024. PMID: 39440198 Free PMC article.
Dengue virus infection in hematopoietic stem cell transplant recipients: A case series and comparative literature review from dengue endemic region.
Shahani W, Fayyaz F, Abdul Samad S, Nizamuddin M, Abid M, Jamal A, Ghayas Z, Rafiq A, Hayee A, Safdar D, Farzana T, Zaidi U. Shahani W, et al. SAGE Open Med Case Rep. 2024 Sep 5;12:2050313X241269637. doi: 10.1177/2050313X241269637. eCollection 2024. SAGE Open Med Case Rep. 2024. PMID: 39246732 Free PMC article.
Interventional antibiotic treatment replacing antibiotic prophylaxis during allogeneic hematopoietic stem cell transplantation is safe and leads to a reduction of antibiotic administration.
Toenges R, Lang F, Ghaffar R, Lindner S, Schlipfenbacher V, Riemann J, Ajib S, Kouidri K, Cremer A, Weber B, Nguyen NTT, Knoch A, Vehreschild J, Serve H, Bug G. Toenges R, et al. Ann Hematol. 2024 Nov;103(11):4687-4699. doi: 10.1007/s00277-024-05986-4. Epub 2024 Sep 6. Ann Hematol. 2024. PMID: 39237814
IL-6-mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation.
Zhang P, Fleming P, Andoniou CE, Waltner OG, Bhise SS, Martins JP, McEnroe BA, Voigt V, Daly S, Kuns RD, Ekwe AP, Henden AS, Saldan A, Olver S, Varelias A, Smith C, Schmidt CR, Ensbey KS, Legg SR, Sekiguchi T, Minnie SA, Gradwell M, Wagenaar I, Clouston AD, Koyama M, Furlan SN, Kennedy GA, Ward ES, Degli-Esposti MA, Hill GR, Tey SK. Zhang P, et al. J Clin Invest. 2024 Apr 1;134(7):e174184. doi: 10.1172/JCI174184. J Clin Invest. 2024. PMID: 38557487 Free PMC article.
Financial Burden as a Potential Barrier to Vaccine Completion in Post-hematopoietic Stem Cell Transplant Patients in Japan.
Ogawa T, Hirai N, Fujikura H, Imakita N, Kasahara K. Ogawa T, et al. Cureus. 2024 Mar 24;16(3):e56842. doi: 10.7759/cureus.56842. eCollection 2024 Mar. Cureus. 2024. PMID: 38528999 Free PMC article.

See all "Cited by" articles

References

1. Tabbara IA, et al. Allogeneic hematopoietic stem cell transplantation: complications and results. Arch Intern Med. 2002;162(14):1558–1566. doi: 10.1001/archinte.162.14.1558. - DOI - PubMed
1. Hiemenz JW. Management of infections complicating allogeneic hematopoietic stem cell transplantation. Semin Hematol. 2009;46(3):289–312. doi: 10.1053/j.seminhematol.2009.03.005. - DOI - PubMed
1. Einsele H, et al. Infectious complications after allogeneic stem cell transplantation: epidemiology and interventional therapy strategies—guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) Ann Hematol. 2003;82(Suppl 2):S175–S185. doi: 10.1007/s00277-003-0772-4. - DOI - PMC - PubMed
1. Ullmann AJ et al (2012) ESCMID* guideline for the diagnosis and management of Candida diseases 2012: developing European guidelines in clinical microbiology and infectious diseases. Clin Microbiol Infect 18(Suppl 7):1–8 - PubMed
1. Cornet M, et al. Efficacy of prevention by high-efficiency particulate air filtration or laminar airflow against Aspergillus airborne contamination during hospital renovation. Infect Control Hosp Epidemiol. 1999;20(7):508–513. doi: 10.1086/501661. - DOI - PubMed

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information

[1] Tabbara IA, et al. Allogeneic hematopoietic stem cell transplantation: complications and results. Arch Intern Med. 2002;162(14):1558–1566. doi: 10.1001/archinte.162.14.1558. - DOI - PubMed

[2] Tabbara IA, et al. Allogeneic hematopoietic stem cell transplantation: complications and results. Arch Intern Med. 2002;162(14):1558–1566. doi: 10.1001/archinte.162.14.1558. - DOI - PubMed

[3] Hiemenz JW. Management of infections complicating allogeneic hematopoietic stem cell transplantation. Semin Hematol. 2009;46(3):289–312. doi: 10.1053/j.seminhematol.2009.03.005. - DOI - PubMed

[4] Hiemenz JW. Management of infections complicating allogeneic hematopoietic stem cell transplantation. Semin Hematol. 2009;46(3):289–312. doi: 10.1053/j.seminhematol.2009.03.005. - DOI - PubMed

[5] Einsele H, et al. Infectious complications after allogeneic stem cell transplantation: epidemiology and interventional therapy strategies—guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) Ann Hematol. 2003;82(Suppl 2):S175–S185. doi: 10.1007/s00277-003-0772-4. - DOI - PMC - PubMed

[6] Einsele H, et al. Infectious complications after allogeneic stem cell transplantation: epidemiology and interventional therapy strategies—guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) Ann Hematol. 2003;82(Suppl 2):S175–S185. doi: 10.1007/s00277-003-0772-4. - DOI - PMC - PubMed

[7] Ullmann AJ et al (2012) ESCMID* guideline for the diagnosis and management of Candida diseases 2012: developing European guidelines in clinical microbiology and infectious diseases. Clin Microbiol Infect 18(Suppl 7):1–8 - PubMed

[8] Ullmann AJ et al (2012) ESCMID* guideline for the diagnosis and management of Candida diseases 2012: developing European guidelines in clinical microbiology and infectious diseases. Clin Microbiol Infect 18(Suppl 7):1–8 - PubMed

[9] Cornet M, et al. Efficacy of prevention by high-efficiency particulate air filtration or laminar airflow against Aspergillus airborne contamination during hospital renovation. Infect Control Hosp Epidemiol. 1999;20(7):508–513. doi: 10.1086/501661. - DOI - PubMed

[10] Cornet M, et al. Efficacy of prevention by high-efficiency particulate air filtration or laminar airflow against Aspergillus airborne contamination during hospital renovation. Infect Control Hosp Epidemiol. 1999;20(7):508–513. doi: 10.1086/501661. - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016

Affiliations

Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016

Authors

Affiliations

Abstract

Comment in

Similar articles

Cited by

References

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Abstract

Comment in

Similar articles

Cited by

References

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical