Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016

Ann Hematol. 2016 Sep;95(9):1435-55. doi: 10.1007/s00277-016-2711-1. Epub 2016 Jun 24.


Infectious complications after allogeneic haematopoietic stem cell transplantation (allo-HCT) remain a clinical challenge. This is a guideline provided by the AGIHO (Infectious Diseases Working Group) of the DGHO (German Society for Hematology and Medical Oncology). A core group of experts prepared a preliminary guideline, which was discussed, reviewed, and approved by the entire working group. The guideline provides clinical recommendations for the preventive management including prophylactic treatment of viral, bacterial, parasitic, and fungal diseases. The guideline focuses on antimicrobial agents but includes recommendations on the use of vaccinations. This is the updated version of the AGHIO guideline in the field of allogeneic haematopoietic stem cell transplantation utilizing methods according to evidence-based medicine criteria.

Keywords: Bacteria; Fungal; Infections; Viral.

MeSH terms

  • Anti-Infective Agents / therapeutic use
  • Bacterial Infections / etiology
  • Bacterial Infections / prevention & control*
  • Germany
  • Hematology / organization & administration
  • Hematopoietic Stem Cell Transplantation / adverse effects
  • Hematopoietic Stem Cell Transplantation / methods*
  • Humans
  • Medical Oncology / organization & administration
  • Mycoses / etiology
  • Mycoses / prevention & control*
  • Parasitic Diseases / etiology
  • Parasitic Diseases / prevention & control*
  • Practice Guidelines as Topic
  • Societies, Medical
  • Transplantation, Homologous
  • Vaccination / methods
  • Virus Diseases / etiology
  • Virus Diseases / prevention & control*


  • Anti-Infective Agents