Biomarker-predicted sugars intake compared with self-reported measures in US Hispanics/Latinos: results from the HCHS/SOL SOLNAS study

Public Health Nutr. 2016 Dec;19(18):3256-3264. doi: 10.1017/S1368980016001580. Epub 2016 Jun 24.


Objective: Measurement error in self-reported total sugars intake may obscure associations between sugars consumption and health outcomes, and the sum of 24 h urinary sucrose and fructose may serve as a predictive biomarker of total sugars intake.

Design: The Study of Latinos: Nutrition & Physical Activity Assessment Study (SOLNAS) was an ancillary study to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) cohort. Doubly labelled water and 24 h urinary sucrose and fructose were used as biomarkers of energy and sugars intake, respectively. Participants' diets were assessed by up to three 24 h recalls (88 % had two or more recalls). Procedures were repeated approximately 6 months after the initial visit among a subset of ninety-six participants.

Setting: Four centres (Bronx, NY; Chicago, IL; Miami, FL; San Diego, CA) across the USA.

Subjects: Men and women (n 477) aged 18-74 years.

Results: The geometric mean of total sugars was 167·5 (95 % CI 154·4, 181·7) g/d for the biomarker-predicted and 90·6 (95 % CI 87·6, 93·6) g/d for the self-reported total sugars intake. Self-reported total sugars intake was not correlated with biomarker-predicted sugars intake (r=-0·06, P=0·20, n 450). Among the reliability sample (n 90), the reproducibility coefficient was 0·59 for biomarker-predicted and 0·20 for self-reported total sugars intake.

Conclusions: Possible explanations for the lack of association between biomarker-predicted and self-reported sugars intake include measurement error in self-reported diet, high intra-individual variability in sugars intake, and/or urinary sucrose and fructose may not be a suitable proxy for total sugars intake in this study population.

Keywords: Doubly labelled water; Hispanics/Latinos; Self-report; Sugars; Urinary sucrose and fructose biomarkers.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biomarkers / urine
  • Diet Surveys*
  • Dietary Sucrose / administration & dosage*
  • Dietary Sucrose / urine
  • Energy Intake
  • Female
  • Fructose / urine
  • Hispanic or Latino*
  • Humans
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Self Report
  • Sugars / administration & dosage*
  • United States
  • Young Adult


  • Biomarkers
  • Dietary Sucrose
  • Sugars
  • Fructose