Restoring stem cells - all you need is NAD(.)

Cell Res. 2016 Sep;26(9):971-2. doi: 10.1038/cr.2016.80. Epub 2016 Jun 24.


The loss of stem cells, through cell dysfunction or senescence, is thought to contribute to biological aging. Recently, Hongbo Zhang and colleagues have shown that activation of the mitochondrial unfolded protein response, a retrograde stress response, through administration with an NAD-raising compound, can rejuvenate stem cells and extend lifespan in mice.

Publication types

  • Comment

MeSH terms

  • Animals
  • Longevity*
  • Mice
  • Mitochondria
  • NAD*
  • Stem Cells
  • Unfolded Protein Response


  • NAD