Fish Oil Supplementation Enhances Pulmonary Strength and Endurance in Women Undergoing Chemotherapy

Nutr Cancer. Aug-Sep 2016;68(6):935-42. doi: 10.1080/01635581.2016.1187282. Epub 2016 Jun 24.

Abstract

We investigated the effect of fish oil (FO) supplementation, at 4 g/day, on the respiratory performance and blood lipid profile of 32 patients with breast cancer at the beginning of chemotherapy. They were randomized into two groups: control (C) and FO supplemented (S). Both groups underwent three respiratory evaluations and blood harvest (before chemotherapy-Day 0, and 30 and 60 days after supplementation). The S group showed a significant increase in the maximal inspiratory and expiratory pressure (P ≤ 0.05 vs. Day 0) and in the maximum voluntary ventilation (P ≤ 0.05). In the treadmill 6-min-walk test, the S group had a significant increase in the walked distance (P ≤ 0.05). Blood lactate concentration was significantly lower in the S group after 60 days, at rest, when compared to C (P ≤ 0.05). Plasma high-density lipoprotein (HDL) cholesterol concentration remained the same after 60 days of supplementation, while in the C group, it decreased significantly (P ≤ 0.05 Day 0 vs. Day 60). Triacylglycerol (TAG) plasma concentration in the S group was lower when compared to the C group (P ≤ 0.05 Day 60S vs. Day 60). Supplementation with FO caused improvement in the respiratory muscle strength and endurance, ameliorated functional performance, and kept TAG, HDL cholesterol, and lactate plasma concentration at normal levels.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Brazil
  • Breast Neoplasms / blood
  • Breast Neoplasms / diet therapy
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / surgery
  • Chemotherapy, Adjuvant / adverse effects
  • Cholesterol, HDL / blood
  • Dietary Supplements* / adverse effects
  • Exercise Test
  • Female
  • Fish Oils / adverse effects
  • Fish Oils / therapeutic use*
  • Humans
  • Lactic Acid / blood
  • Lung / drug effects*
  • Lung / physiopathology
  • Middle Aged
  • Muscle Strength / drug effects
  • Physical Endurance / drug effects*
  • Postoperative Care
  • Postoperative Complications / chemically induced
  • Postoperative Complications / physiopathology
  • Postoperative Complications / prevention & control
  • Reproducibility of Results
  • Respiratory Insufficiency / chemically induced
  • Respiratory Insufficiency / etiology
  • Respiratory Insufficiency / physiopathology
  • Respiratory Insufficiency / prevention & control*
  • Respiratory Muscles / drug effects
  • Respiratory Muscles / physiopathology
  • Triglycerides / blood

Substances

  • Antineoplastic Agents
  • Cholesterol, HDL
  • Fish Oils
  • Triglycerides
  • Lactic Acid