The Role of Oxidative Stress and Inflammatory Mediators in Benign Paroxysmal Positional Vertigo

J Int Adv Otol. 2016 Apr;12(1):101-5. doi: 10.5152/iao.2015.1412.


Objective: Benign paroxysmal positional vertigo (BPPV) is the most common peripheral cause of vertigo. It can be defined as transient vertigo induced by rapid changes in head position associated with a characteristic paroxysmal positional nystagmus. The aim of this study was to search for the possible role of oxidative stress and inflammatory mediators in the pathogenesis of BPPV.

Materials and methods: Total antioxidant status as well as paraoxonase, tumor necrosis factor alpha, interleukin (IL) 6, and IL-1β levels were evaluated in peripheral venous serum samples of 30 BPPV and 30 control patients.

Results: Total antioxidant status levels were lower in the BPPV group than in the control group (p=0.008). After Epley's repositioning maneuver in the vertigo group, there was a statistically significant decline in IL-1β levels at the first and third month visits (p=0.014 for first month and p=0.013 for third month).

Conclusion: Our findings suggested that IL-1β and oxidative stress contributed to the pathogenesis of BPPV.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aryldialkylphosphatase / blood
  • Benign Paroxysmal Positional Vertigo / diagnosis
  • Benign Paroxysmal Positional Vertigo / physiopathology*
  • Female
  • Humans
  • Inflammation Mediators / blood*
  • Interleukin-1beta / blood
  • Interleukin-6 / blood
  • Male
  • Middle Aged
  • Oxidative Stress / physiology*
  • Reference Values
  • Tumor Necrosis Factor-alpha / blood


  • Inflammation Mediators
  • Interleukin-1beta
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • Aryldialkylphosphatase
  • PON1 protein, human