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. 2016 Jul 15;18(14):3338-41.
doi: 10.1021/acs.orglett.6b01437. Epub 2016 Jun 24.

Pseudoxylallemycins A-F, Cyclic Tetrapeptides With Rare Allenyl Modifications Isolated From Pseudoxylaria Sp. X802: A Competitor of Fungus-Growing Termite Cultivars

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Pseudoxylallemycins A-F, Cyclic Tetrapeptides With Rare Allenyl Modifications Isolated From Pseudoxylaria Sp. X802: A Competitor of Fungus-Growing Termite Cultivars

Huijuan Guo et al. Org Lett. .

Abstract

Based on fungus-fungus pairing assays and HRMS-based dereplication strategy, six new cyclic tetrapeptides, pseudoxylallemycins A-F (1-6), were isolated from the termite-associated fungus Pseudoxylaria sp. X802. Structures were characterized using NMR spectroscopy, HRMS, and Marfey's reaction. Pseudoxylallemycins B-D (2-4) possess a rare and chemically accessible allene moiety amenable for synthetic modifications, and derivatives A-D showed antimicrobial activity against Gram-negative human-pathogenic Pseudomonas aeruginosa and antiproliferative activity against human umbilical vein endothelial cells and K-562 cell lines.

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