In the late 1960s, a series of epidemiological studies of educational and behavioural problems in middle childhood was undertaken on the Isle of Wight. In 1970, similar methods were used with an inner London sample of 10-year-olds to explore area differences in prevalence rates and correlates. Members of the London cohort have since been followed-up through their teens, to assess the longer-term implications of such problems for educational attainments, early employment prospects, and adolescent behavioural difficulties. School influences on children's development also constituted a central focus of these later stages of the work. This paper draws together the main findings of the London studies to date, and includes a full list of the main publications.