Carnosine and the processes of ageing

Maturitas. 2016 Nov;93:28-33. doi: 10.1016/j.maturitas.2016.06.002. Epub 2016 Jun 22.

Abstract

The causes of ageing are usually regarded as multifactorial; thus effective regulation might be achieved by intervention at multiple sites. It has been suggested that the endogenous dipeptide carnosine, also available as a food supplement, possesses anti-ageing activity and may achieve its reported age-alleviating effects via a number of mechanisms. Carnosine's possible anti-ageing mechanisms are therefore discussed; the evidence suggests that inhibition of the mechanistic target of rapamycin and carbonyl scavenging may be involved.

Keywords: Advanced glycation end products; Ageing; Carnosine; Inflammation; Oxidative stress; Signalling pathways.

Publication types

  • Review

MeSH terms

  • Aging / metabolism*
  • Animals
  • Carnosine / metabolism*
  • Dietary Supplements
  • Humans
  • Inflammation / metabolism*
  • Oxidative Stress / physiology*
  • Signal Transduction / physiology

Substances

  • Carnosine