Noble metal nanoparticle-induced oxidative stress modulates tumor associated macrophages (TAMs) from an M2 to M1 phenotype: An in vitro approach

Int Immunopharmacol. 2016 Sep:38:332-41. doi: 10.1016/j.intimp.2016.06.006. Epub 2016 Jun 23.

Abstract

Diagnosis of cancer and photothermal therapy using optoelectronic properties of noble metal nanoparticles (NPs) has established a new therapeutic approach for treating cancer. Here we address the intrinsic properties of noble metal NPs (gold and silver) as well as the mechanism of their potential antitumor activity. For this, the study addresses the functional characterization of tumor associated macrophages (TAMs) isolated from murine fibrosarcoma induced by a chemical carcinogen, 3-methylcholanthrene (MCA). We have previously shown antitumor activity of both gold nanoparticles (AuNPs) and silver nanoparticle (AgNPs) in vivo in a murine fibrosarcoma model. In the present study, it has been seen that AuNPs and AgNPs modulate the reactive oxygen species (ROS) and reactive nitrogen species (RNS) production, suppressing the antioxidant system of cells (TAMs). Moreover, the antioxidant-mimetic action of these NPs maintain the ROS and RNS levels in TAMs which act as second messengers to activate the proinflammatory signaling cascades. Thus, while there is a downregulation of tumor necrosis factor-α (TNF-α) and Interleukin-10 (IL-10) in the TAMs, the proinflammatory cytokine Interleukin-12 (IL-12) is upregulated resulting in a polarization of TAMs from M2 (anti-inflammatory) to M1 (pro-inflammatory) nature.

Keywords: Chemical carcinogen; Gold nanoparticles; Noble metal nanoparticles; RNS; ROS; Silver nanoparticles; TAMs.

MeSH terms

  • Animals
  • Cell Differentiation
  • Cells, Cultured
  • Fibrosarcoma / chemically induced
  • Fibrosarcoma / immunology*
  • Gold / chemistry
  • Interleukin-10 / metabolism
  • Interleukin-12 / metabolism
  • Macrophages / physiology*
  • Male
  • Metal Nanoparticles / administration & dosage*
  • Metal Nanoparticles / chemistry
  • Methylcholanthrene / toxicity
  • Mice
  • Oxidative Stress
  • Phenotype
  • Reactive Oxygen Species / metabolism
  • Silver / chemistry
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Reactive Oxygen Species
  • Tumor Necrosis Factor-alpha
  • Interleukin-10
  • Interleukin-12
  • Silver
  • Methylcholanthrene
  • Gold