Hypothermia for neonatal hypoxic-ischemic encephalopathy: NICHD Neonatal Research Network contribution to the field

Semin Perinatol. 2016 Oct;40(6):385-390. doi: 10.1053/j.semperi.2016.05.009. Epub 2016 Jun 23.

Abstract

In this article, we summarize the NICHD Neonatal Research Network (NRN) trial of whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy in relation to other randomized controlled trials (RCTs) of hypothermia neuroprotection. We describe the NRN secondary studies that have been published in the past 10 years evaluating clinical, genetic, biochemical, and imaging biomarkers of outcome.

Keywords: Biomarkers; Hypothermia Neuroprotection; Hypoxic-ischemic encephalopathy; Neonatal.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Child Development
  • Developmental Disabilities / mortality
  • Developmental Disabilities / physiopathology*
  • Humans
  • Hypothermia, Induced*
  • Hypoxia-Ischemia, Brain* / mortality
  • Hypoxia-Ischemia, Brain* / physiopathology
  • Hypoxia-Ischemia, Brain* / therapy
  • Infant, Newborn
  • Intensive Care Units, Neonatal
  • National Institute of Child Health and Human Development (U.S.)*
  • Randomized Controlled Trials as Topic
  • Survival Analysis
  • Time Factors
  • Treatment Outcome
  • United States