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. 2016 Aug;44(8):1095-103.
doi: 10.1016/j.jcms.2016.05.025. Epub 2016 Jun 7.

Primary Stability and Osseointegration of Dental Implants in Polylactide Modified Bone - A Pilot Study in Goettingen Minipigs

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Primary Stability and Osseointegration of Dental Implants in Polylactide Modified Bone - A Pilot Study in Goettingen Minipigs

Phillipp Brockmeyer et al. J Craniomaxillofac Surg. .

Abstract

The present study aimed to evaluate primary stability (PS) and osseointegration of dental implants in polylactide [70/30 poly(l-lactide-co-d, l-lactide); (PLDLA)] modified bone in 30 Goettingen minipigs. Each animal received three implants per jaw quadrant. In a split-mouth design, one side of the maxilla and mandible was randomly allocated to the experimental treatment (PLDLA applied into the drill hole before implantation), while the contralateral sides served as intraindividual controls (no PLDLA applied). The required insertion torque and the implant stability quotient (ISQ) were measured during implantation. ISQ, volume density (VD) of new bone formation (NBF), and the bone-implant contact (BIC) were evaluated at the end of the observation period (1, 3, 6, 12, and 24 months, respectively) in six animals each. Across all study groups, the PLDLA treatment resulted in a) a comparable insertion torque, b) an equivalent ISQ, c) a reduced BIC, and d) a reduced VD of NBF, as opposed to the untreated controls. In conclusion, the PLDLA treatment did not affect the PS, but rather led to an impaired osseointegration, which was particularly strong in the compact mandibular bone, and decreased in the spongious maxillary bone. PLDLA induced anchoring in spongious bone should be evaluated in further investigations.

Keywords: 70/30 poly(l-lactide-co-d, l-lactide); Dental implants; Osseointegration; Polylactide modified bone; Primary stability.

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