Topographic comparison of MMN to simple versus pattern regularity violations: The effect of timing

Neurosci Res. 2016 Nov;112:20-25. doi: 10.1016/j.neures.2016.06.004. Epub 2016 Jun 24.

Abstract

Mismatch negativity (MMN) is generated by sounds violating a regular sequence of events including simple regularities related to repetition of acoustic features (e.g. a tone frequency) as well as abstract regularities hidden in stimuli relationships (e.g. a pattern of frequency change). The aim of present study was to investigate whether time interval between the sound events, being either shorter or longer than temporal window of integration (TWI), affects the dissociated processing of simple versus pattern regularities along the auditory deviance detection system. MMN was recorded in healthy young adults during simple and pattern frequency oddball paradigms, using two different SOAs of 180 and 270ms, and the MMN topographic distribution was compared using global dissimilarity index (DISS). There was a significant difference between simple and pattern MMN topographies using an SOA of 270ms (DISS=0.8349, p<0.05) but no significant difference was found with an SOA of 180ms (DISS=0.2516, p=0.84). These results indicate that timing can modulate the dissociation between the cortical areas involved in simple and pattern regularity encoding so that at SOAs shorter than TWI, the processing of these regularities share more similar neural circuits compared to the long SOAs.

Keywords: Auditory change detection; Mismatch negativity; Pattern regularities; Timing; Topography.

Publication types

  • Comparative Study

MeSH terms

  • Acoustic Stimulation
  • Adult
  • Brain / physiology*
  • Brain Mapping
  • Electroencephalography
  • Evoked Potentials, Auditory*
  • Female
  • Humans
  • Male
  • Time Factors
  • Young Adult