Determination and Validation of Thresholds of Anterior Chamber Parameters by Dedicated Anterior Segment Optical Coherence Tomography

Am J Ophthalmol. 2016 Sep;169:208-217. doi: 10.1016/j.ajo.2016.06.032. Epub 2016 Jun 25.

Abstract

Purpose: To determine and validate thresholds of anterior chamber angle (ACA) parameters in discriminating open- vs narrow-angle eyes using images from dedicated anterior segment optical coherence tomography (DASOCT).

Design: Reliability analysis.

Methods: Eyes imaged by DASOCT and examined with gonioscopy were reviewed. By gonioscopy, eyes were classified as narrow if posterior trabecular meshwork was not visible and open if the angle was open to scleral spur and beyond. Imaging was performed in the dark with the CASIA SS-1000 (Tomey, Nagoya, Japan). ACA parameters angle opening distance (AOD), trabecular-iris space area (TISA), trabecular-iris circumference volume (TICV), length of iridotrabecular contact (ITC), and extent and area of ITC were calculated. AOD, TISA, and TICV were measured at both 500 μm and 750 μm from the scleral spur landmark. Study eyes were randomly divided into training and testing sets. Thresholds were calculated from the training set. Sensitivity, specificity, and agreement were then calculated against the clinical classification using the testing set.

Results: One hundred and eighty-nine eyes (111 open, 78 narrow, including 8 borderline angles) were included. Using the threshold determined in the training set on the testing set, 9 of 24 ACA parameters had no misclassification of narrow-angle eyes as open (sensitivity = 1.0). Of 9 parameters, the specificity was >0.79. The highest kappa values (kappa = 0.91) was AOD750 inferiorly at 0.31 mm threshold, followed by both TICV500 at 1.92 μL and TICV750 at 4.00 μL with kappa = 0.86.

Conclusion: The parameters with the best discriminative ability for detecting narrow angles were AOD750 inferiorly, TICV500, and TICV750.

Publication types

  • Validation Study

MeSH terms

  • Anterior Chamber / diagnostic imaging
  • Anterior Chamber / pathology*
  • Area Under Curve
  • Diagnosis, Differential
  • Female
  • Glaucoma, Angle-Closure / diagnosis*
  • Glaucoma, Open-Angle / diagnosis*
  • Gonioscopy
  • Humans
  • Intraocular Pressure
  • Iris / diagnostic imaging
  • Iris / pathology*
  • Male
  • Middle Aged
  • ROC Curve
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Tomography, Optical Coherence / methods
  • Trabecular Meshwork / diagnostic imaging
  • Trabecular Meshwork / pathology*