Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development

FEBS Lett. 2016 Aug;590(16):2584-93. doi: 10.1002/1873-3468.12271. Epub 2016 Jul 14.


C2cd4c, encoded by a gene belonging to the C2cd4 family, contains a C2 domain conserved across species and is localized to the cytoplasm. To examine the role of C2cd4c in the pancreas, we studied its localization and generated C2cd4c knockout (KO) mice. C2cd4c was expressed in pancreatic endocrine progenitors at early embryonic stages. When endocrine cells arise from their precursors, C2cd4c is gradually confined to the insulin- and pancreatic polypeptide-expressing cells of the endocrine. In the adult pancreas, C2cd4c is restricted to the beta cells. C2cd4c KO mice showed normal embryonic pancreatic development and adult pancreatic function. Thus, our results suggest that C2cd4c is dispensable for pancreatic development.

Keywords: C2cd4; insulin; pancreas; pancreatic beta cell.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium-Binding Proteins / genetics*
  • Cell Differentiation / genetics
  • Cell Lineage / genetics
  • Gene Expression Regulation, Developmental
  • Insulin / genetics
  • Insulin / metabolism*
  • Insulin-Secreting Cells / metabolism
  • Islets of Langerhans / growth & development
  • Islets of Langerhans / metabolism*
  • Membrane Proteins / biosynthesis*
  • Membrane Proteins / genetics
  • Mice
  • Mice, Knockout
  • Pancreas / growth & development
  • Pancreas / metabolism*


  • C2cd4c protein, mouse
  • Calcium-Binding Proteins
  • Insulin
  • Membrane Proteins

Associated data

  • GENBANK/NP_001074783.1
  • GENBANK/NP_001129589.1
  • GENBANK/NP_001135670.1
  • GENBANK/NP_001156615.1
  • GENBANK/NP_001162095.1
  • GENBANK/NP_001181749.1
  • GENBANK/XP_008763400.1
  • GENBANK/XP_015155493.1