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. 2016 Jun 3:12:1303-8.
doi: 10.2147/NDT.S105478. eCollection 2016.

Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study

Xin Huang  1 , Sheng-Hong Li  2 , Fu-Qing Zhou  2 , Ying Zhang  3 , Yu-Lin Zhong  3 , Feng-Qin Cai  2 , Yi Shao  3 , Xian-Jun Zeng  2
Affiliations

Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study

Xin Huang et al. Neuropsychiatr Dis Treat. .

Abstract

Objective: To investigate the underlying regional homogeneity (ReHo) of brain-activity abnormalities in patients with comitant strabismus (CS) and their relationship with behavioral performance.

Methods: Twenty patients with CS (ten men and ten women) and 20 (ten men and ten women) age-, sex-, and education-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging scans. The ReHo method was used to assess local features of spontaneous brain activities. Patients with CS were distinguished from HCs by receiver operating characteristic curve. Correlation analysis was performed to explore the relationship between the observed mean ReHo values of the different brain areas and behavioral performance.

Results: Compared to HCs, the patients with CS showed significantly increased ReHo values in the right inferior temporal cortex/fusiform gyrus/cerebellum anterior lobe, right lingual gyrus, and bilateral cingulate gyrus. We did not find any relationship between the observed mean ReHo values of the different brain areas and behavioral performance.

Conclusion: CS causes dysfunction in many brain regions, which may explain the fusion compensation in CS.

Keywords: comitant strabismus; functional magnetic resonance imaging; regional homogeneity; resting state.

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Figures

Figure 1
Figure 1
Significant differences in ReHo values between the Stra group and HCs. Notes: The brain regions with different ReHo values are the RITC/RFG/RCAL (A), RLG (B), and BCG (C). The red areas denote higher ReHo brain regions. Multiple comparisons were performed using Gaussian random field theory (z >2.3, clusterwise P<0.05 corrected). T-values indicates the results of independent t-tests comparing the two groups in ReHo values in different brain regions. Abbreviations: BCG, bilateral cingulate gyrus; HCs, healthy controls; RCAL, right cerebellum anterior lobe; ReHo, regional homogeneity; RFG, right fusiform gyrus; RITC, right inferior temporal cortex; RLG, right lingual gyrus; Stra, strabismus.
Figure 2
Figure 2
Mean of altered ReHo values between the Stra group and HCs. Abbreviations: BCG, bilateral cingulate gyrus; HCs, healthy controls; RCAL, right cerebellum anterior lobe; ReHo, regional homogeneity; RFG, right fusiform gyrus; RITC, right inferior temporal cortex; RLG, right lingual gyrus; Stra, strabismus.
Figure 3
Figure 3
ROC curve analysis of the mean ReHo signal values for altered brain regions. Notes: The area under the ROC curve was 0.938 (P<0.001; 95% CI: 0.864–1) for the RITC/RFG/RCAL (A), and 0.940 (P<0.001; 95% CI 0.870–1) for the BCG (B). Abbreviations: BCG, bilateral cingulate gyrus; CI, confidence interval; RCAL, right cerebellum anterior lobe; ReHo, regional homogeneity; RFG, right fusiform gyrus; RITC, right inferior temporal cortex; ROC, receiver operating characteristic.
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