Mitochondrial complex I and V gene polymorphisms in type II diabetes mellitus among high risk Mizo-Mongoloid population, Northeast India

Freda Lalrohlui; Sunaina Thapa; Souvik Ghatak; John Zohmingthanga; Nachimuthu Senthil Kumar

doi:10.1186/s41021-016-0034-z

Mitochondrial complex I and V gene polymorphisms in type II diabetes mellitus among high risk Mizo-Mongoloid population, Northeast India

Genes Environ. 2016 Mar 1:38:5. doi: 10.1186/s41021-016-0034-z. eCollection 2016.

Authors

Freda Lalrohlui¹, Sunaina Thapa¹, Souvik Ghatak¹, John Zohmingthanga², Nachimuthu Senthil Kumar¹

Affiliations

¹ Department of Biotechnology, Mizoram University, Aizawl, 796004 Mizoram India.
² Department of Pathology, Civil Hospital, Aizawl, 796001 Mizoram India.

Abstract

Introduction: The study was carried out to identify the polymorphisms in mitochondrial genes (ATPase and ND1) in type 2 Diabetes Mellitus (T2DM) from Mizo population and to correlate the involvement of demographic factors.

Findings: In the present study, 58 patients and 50 healthy volunteers were considered. The mutations observed were mostly base substitutions and were similar as reported for other populations. Three mutations are unreported and were found to be novel polymorphisms for diabetic disease. One heteroplasmic variation (MT3970 C > T) was found in 36.36 % of samples. Subjects with excessive smoked meat consumption and customary habit of smoking (ORs: 4.92; 95 % CI: 0.96-25.21) were found to be more prone to T2DM. Mitochondrial genes sequence analysis revealed the genetic variability between the healthy and diabetic samples.

Conclusion: Mitochondrial ATPase and ND1 gene polymorphisms may be involved in triggering the risk for T2DM.

Keywords: Demography; Genetic variability; Mitochondrial genes; Polymorphism; Type 2 diabetes mellitus.