Case Report: GcMAF Treatment in a Patient with Multiple Sclerosis

Anticancer Res. 2016 Jul;36(7):3771-4.


Background/aim: Gc protein-derived macrophage-activating factor (GcMAF) has various functions as an immune modulator, such as macrophage activation, anti-angiogenic activity and anti-tumor activity. Clinical trials of second-generation GcMAF demonstrated remarkable clinical effects in several types of cancers. Thus, GcMAF-based immunotherapy has a wide application for use in the treatment of many diseases via macrophage activation that can be used as a supportive therapy. Multiple sclerosis (MS) is considered to be an autoimmune disorder that affects the myelinated axons in the central nervous system (CNS). This study was undertaken to examine the effects of second-generation GcMAF in a patient with MS.

Results: This case study demonstrated that treatments of GcMAF in a patient with MS have potent therapeutic actions with early beneficial responses, especially improvement of motor dysfunction.

Conclusion: GcMAF shows therapeutic potency in the treatment of MS.

Keywords: GcMAF; Immunotherapy; colostrum MAF; macrophage activating factor (MAF); motor dysfunction; multiple sclerosis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Humans
  • Immunologic Factors / pharmacology
  • Immunologic Factors / therapeutic use*
  • Immunotherapy
  • Locomotion / drug effects
  • Macrophage-Activating Factors / pharmacology
  • Macrophage-Activating Factors / therapeutic use*
  • Male
  • Multiple Sclerosis / drug therapy*
  • Multiple Sclerosis / physiopathology
  • Remission Induction
  • Treatment Outcome
  • Vitamin D-Binding Protein / pharmacology
  • Vitamin D-Binding Protein / therapeutic use*


  • Immunologic Factors
  • Macrophage-Activating Factors
  • Vitamin D-Binding Protein
  • vitamin D-binding protein-macrophage activating factor