DNA-catalyzed glycosylation using aryl glycoside donors

Chem Commun (Camb). 2016 Jul 28;52(59):9259-62. doi: 10.1039/c6cc04329a. Epub 2016 Jun 29.


We report the identification by in vitro selection of Zn(2+)/Mn(2+)-dependent deoxyribozymes that glycosylate the 3'-OH of a DNA oligonucleotide. Both β and α anomers of aryl glycosides can be used as the glycosyl donors. Individual deoxyribozymes are each specific for a particular donor anomer.

MeSH terms

  • Biocatalysis*
  • DNA, Catalytic / chemistry
  • DNA, Catalytic / metabolism*
  • Glycosides / chemistry
  • Glycosides / metabolism*
  • Glycosylation


  • DNA, Catalytic
  • Glycosides