Physiology: Stressed-out chromatin promotes longevity

Nature. 2016 Jun 30;534(7609):625-6. doi: 10.1038/534625a.

Abstract

Two studies reveal that early-life malfunction in organelles called mitochondria brings about lasting changes in how DNA is packaged. These alterations have consequences for cellular stress responses and organismal longevity.

MeSH terms

  • Aging / genetics*
  • Aging / pathology
  • Animals
  • Caenorhabditis elegans / cytology
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans / physiology
  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / metabolism
  • Chromatin / genetics*
  • Chromatin / metabolism
  • Epigenesis, Genetic / genetics*
  • Free Radicals / metabolism
  • Heat-Shock Response
  • Histone Demethylases / genetics
  • Histone Demethylases / metabolism
  • Histones / chemistry
  • Histones / metabolism
  • Jumonji Domain-Containing Histone Demethylases / genetics
  • Jumonji Domain-Containing Histone Demethylases / metabolism
  • Longevity / genetics*
  • Longevity / physiology*
  • Mitochondria / pathology*
  • Stress, Physiological / genetics*
  • Stress, Physiological / physiology
  • Unfolded Protein Response / genetics
  • Unfolded Protein Response / physiology

Substances

  • Caenorhabditis elegans Proteins
  • Chromatin
  • Free Radicals
  • Histones
  • Histone Demethylases
  • JMJD-1.2 protein, C elegans
  • JMJD-3.1 protein, C elegans
  • Jumonji Domain-Containing Histone Demethylases