Coronary heart disease in Greenland Inuit: a paradox. Implications for western diet patterns

Arctic Med Res. 1989 Apr;48(2):47-54.

Abstract

Epidemiologic examinations of Greenland Inuit have disclosed a connection between high seafood intake containing a high level of n-3 polyunsaturated fatty acids (PUFAs) and a low coronary heart disease (CHD) morbidity. Other epidemiologic studies have confirmed this interrelation, and a biological substrate for a causal relationship has been established. This includes a lipid lowering effect of n-3 PUFAs and a modulatory effect on eicosanoid metabolism, shifting platelet vessel wall balance in an antithrombotic direction. Other metabolic effects of n-3 PUFAs are an altered inflammatory response to proinflammatory stimuli and a modest hypotensive effect. These findings create a basis for controlled clinical studies and justify, in the author's opinion, both a mass strategy of advocating that a well-balanced diet should include a higher use of seafood in Western diets, and a more intensive recommendation of n-3 PUFAs in certain high-risk patients with a heterogeneous risk-factor profile. Among these, patients with essential hypertension and patients undergoing reconstructive coronary intervention are obvious candidates. A major outcome of the research, stemming from the epidemiological studies, is establishment of the fact that separate attention should be paid to both the n-6 and the n-3 fatty acids.

MeSH terms

  • Adult
  • Aged
  • Coronary Disease / epidemiology*
  • Coronary Disease / ethnology
  • Denmark
  • Dietary Fats / administration & dosage*
  • Fatty Acids, Unsaturated / administration & dosage
  • Female
  • Fish Oils / administration & dosage
  • Greenland
  • Humans
  • Inuits*
  • Male
  • Middle Aged

Substances

  • Dietary Fats
  • Fatty Acids, Unsaturated
  • Fish Oils