Eruptive Facial Postinflammatory Lentigo: Clinical and Dermatoscopic Features

Am J Dermatopathol. 2016 Nov;38(11):813-819. doi: 10.1097/DAD.0000000000000606.


The face has not been considered a common site of fixed drug eruption, and the authors lack dermatoscopic studies of this condition on the subject. The authors sought to characterize clinical and dermatoscopic features of 8 cases of an eruptive facial postinflammatory lentigo. The authors conducted a retrospective review of 8 cases with similar clinical and dermatoscopic findings seen from 2 medical centers in 2 countries during 2010-2014. A total of 8 patients (2 males and 6 females) with ages that ranged from 34 to 62 years (mean: 48) presented an abrupt onset of a single facial brown-pink macule, generally asymmetrical, with an average size of 1.9 cm. after ingestion of a nonsteroidal antiinflammatory drugs that lasted for several months. Dermatoscopy mainly showed a pseudonetwork or uniform areas of brown pigmentation, brown or blue-gray dots, red dots and/or telangiectatic vessels. In the epidermis, histopathology showed a mild hydropic degeneration and focal melanin hyperpigmentation. Melanin can be found freely in the dermis or laden in macrophages along with a mild perivascular mononuclear infiltrate. The authors describe eruptive facial postinflammatory lentigo as a new variant of a fixed drug eruption on the face.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Biomarkers / analysis
  • Biopsy
  • Chile
  • Dermoscopy*
  • Drug Eruptions / etiology
  • Drug Eruptions / metabolism
  • Drug Eruptions / pathology*
  • Facial Dermatoses / chemically induced
  • Facial Dermatoses / metabolism
  • Facial Dermatoses / pathology*
  • Female
  • Humans
  • Hyperpigmentation / chemically induced
  • Hyperpigmentation / pathology
  • Lentigo / chemically induced
  • Lentigo / metabolism
  • Lentigo / pathology*
  • Male
  • Melanins / analysis
  • Middle Aged
  • Predictive Value of Tests
  • Retrospective Studies
  • Risk Factors
  • Skin / chemistry
  • Skin / drug effects
  • Skin / pathology*
  • Spain


  • Anti-Inflammatory Agents, Non-Steroidal
  • Biomarkers
  • Melanins