C3 nephritic factor and C4 nephritic factor in the serum of two patients with hypocomplementaemic membranoproliferative glomerulonephritis

Y Tanuma; H Ohi; S Watanabe; M Seki; M Hatano

C3 nephritic factor and C4 nephritic factor in the serum of two patients with hypocomplementaemic membranoproliferative glomerulonephritis

Clin Exp Immunol. 1989 Apr;76(1):82-5.

Authors

Y Tanuma¹, H Ohi, S Watanabe, M Seki, M Hatano

Affiliation

¹ Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.

PMID: 2736802
PMCID: PMC1541731

Abstract

Both C3 nephritic factor (C3NeF) and C4 nephritic factor (C4NeF) were found in the serum of two patients with hypocomplementaemic membranoproliferative glomerulonephritis type 1 (H-MPGN type 1). Both stabilizing activities were associated with the IgG fraction. The serum levels of C3 and C5 were quite low, whereas the levels of early components and control proteins were in the normal range.

MeSH terms

Adolescent
Adult
Autoantibodies / analysis*
Complement C3 / analysis
Complement C3 Nephritic Factor / analysis*
Complement C4 / analysis
Complement C5 / analysis
Complement Inactivator Proteins / analysis*
Complement System Proteins / analysis*
Female
Glomerulonephritis, Membranoproliferative / immunology*
Humans
Immunoglobulin G / immunology
Male

Substances

Autoantibodies
Complement C3
Complement C3 Nephritic Factor
Complement C4
Complement C5
Complement Inactivator Proteins
Immunoglobulin G
complement 4 nephritic factor
Complement System Proteins