Blood pressure and cerebral haemorrhage and ischaemia in very low birthweight infants

Early Hum Dev. 1989 May;19(2):103-10. doi: 10.1016/0378-3782(89)90120-5.


Hourly blood pressures were recorded directly in 131 very low birth weight infants in intensive care during the first 4 days of life. Cranial ultrasound evidence of intraventricular haemorrhage correlated well with periods of hypotension, but not of hypertension. Ischaemic lesions did not correlate with periods of hypotension, but were associated with previous haemorrhage. The findings suggest that hypotension predisposes to primary intraventricular haemorrhage and that later parenchymal ischaemic lesions relate to local factors rather than hypotension.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Ischemia / etiology*
  • Brain Ischemia / physiopathology
  • Cerebral Hemorrhage / etiology*
  • Cerebral Hemorrhage / physiopathology
  • Female
  • Humans
  • Hypotension / etiology*
  • Hypotension / physiopathology
  • Infant, Low Birth Weight*
  • Infant, Newborn
  • Male