Eosinophil polyunsaturated fatty acid metabolism and its potential control of inflammation and allergy

Allergol Int. 2016 Sep;65 Suppl:S2-5. doi: 10.1016/j.alit.2016.05.010. Epub 2016 Jun 29.

Abstract

Polyunsaturated fatty acids (PUFAs) exhibit a range of biological effects, many of which are mediated through the formation and actions of their bioactive metabolites. It is well appreciated that dietary PUFA balance affects inflammation and/or allergic diseases, and recent advances in liquid chromatography tandem mass spectrometry (LC-MS/MS)-based mediator lipidomics have revealed a potential link between PUFA metabolism and biological phenotypes. This review presents insights into the emerging roles of eosinophil PUFA metabolism in controlling inflammatory responses and its potential involvement in allergy control.

Keywords: Eosinophil; Lipid mediator; Lipidomics; Lipoxygenase; n-3 fatty acid.

Publication types

  • Review

MeSH terms

  • Animals
  • Eosinophils / immunology
  • Eosinophils / metabolism*
  • Fatty Acids, Unsaturated / metabolism*
  • Humans
  • Hypersensitivity / immunology
  • Hypersensitivity / metabolism*
  • Inflammation / immunology
  • Inflammation / metabolism*
  • Lipid Metabolism
  • Signal Transduction

Substances

  • Fatty Acids, Unsaturated