Accelerated chemical shift imaging of hyperpolarized (13) C metabolites

Magn Reson Med. 2016 Oct;76(4):1033-8. doi: 10.1002/mrm.26286. Epub 2016 Jul 4.


Purpose: Chemical shift imaging (CSI) has long been considered the gold standard method for in vivo hyperpolarized (13) C metabolite imaging because of its high sensitivity. However, CSI requires a large number of excitations so it is desirable to reduce the number of RF excitations and the total acquisition time.

Methods: Centric phase encoding and three-dimensional compressed sensing methods were adopted into a CSI acquisition to improve efficiency and reduce the number of excitations required for imaging hyperpolarized metabolites. The new method was implemented on a GE MR750W scanner for routine real time metabolic imaging experiments.

Results: Imaging results from phantoms and in vivo animals using hyperpolarized (13) C tracers demonstrate that when the entire CSI dataset is treated as a single object, compressed sensing can be satisfactorily applied to spectroscopic CSI. Centric k-space trajectory data collection also greatly improves the acquisition efficiency. This combination of compressed sensing CSI and acquisition time reduction was used to perform a hyperpolarized (13) C dynamic study.

Conclusion: Compressed sensing can be satisfactorily applied to conventional CSI in hyperpolarized (13) C metabolite MR imaging to reduce the number of RF excitations and accelerate the imaging speed to take advantage of conventional CSI in providing high sensitivity and a large spectral bandwidth. Magn Reson Med 76:1033-1038, 2016. © 2016 Wiley Periodicals, Inc.

Keywords: chemical shift imaging (CSI); compressed sensing; hyperpolarized 13C MRI; in-vivo MRI.

Publication types

  • Evaluation Study

MeSH terms

  • Algorithms
  • Animals
  • Carbon Isotopes / pharmacokinetics*
  • Carbon-13 Magnetic Resonance Spectroscopy / methods*
  • Kidney / metabolism*
  • Lactic Acid / metabolism*
  • Magnetic Resonance Imaging / methods*
  • Molecular Imaging / methods
  • Pyruvic Acid / metabolism*
  • Rats
  • Rats, Sprague-Dawley
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Tissue Distribution


  • Carbon Isotopes
  • Lactic Acid
  • Pyruvic Acid