Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response

Biochim Biophys Acta. 2016 Aug;1866(1):87-105. doi: 10.1016/j.bbcan.2016.06.005. Epub 2016 Jul 8.


Increased glycolysis is the main source of energy supply in cancer cells that use this metabolic pathway for ATP generation. Altered energy metabolism is a biochemical fingerprint of cancer cells that represents one of the "hallmarks of cancer". The immune system can prevent tumour growth by eliminating cancer cells but this editing process ultimately results in poorly immunogenic cells remaining allowing for unchallenged tumour growth. In this review we look at the glycolysis pathway as a target for cancer treatments. We also examine the interplay between the glycolysis modulation and the immune response as an anti-cancer therapy.

Keywords: Electroporation; Glycolysis; Glycolytic modulator; Immune-metabolic interaction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Energy Metabolism / drug effects
  • Glycolysis / drug effects*
  • Humans
  • Immunity, Cellular / drug effects*
  • Metabolic Networks and Pathways / drug effects
  • Molecular Targeted Therapy
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism
  • Neoplasms / pathology


  • Adenosine Triphosphate