Co-administration of cannabidiol and capsazepine reduces L-DOPA-induced dyskinesia in mice: Possible mechanism of action

Neurobiol Dis. 2016 Oct:94:179-95. doi: 10.1016/j.nbd.2016.06.013. Epub 2016 Jun 29.
No abstract available

Keywords: AIMs; Anandamide; CB1; COX-2; Cannabinoid; ERK 1/2; LID; NF-κB; Neuroinflammation; PPAR gamma; TRPV-1; pAcH3.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Dyskinesia Agents / pharmacology*
  • Anti-Dyskinesia Agents / toxicity*
  • Arachidonic Acids / metabolism
  • Brain / drug effects
  • Brain / pathology
  • Cannabidiol / pharmacology*
  • Capsaicin / analogs & derivatives*
  • Capsaicin / pharmacology
  • Cyclooxygenase 2 / metabolism
  • Dyskinesia, Drug-Induced / drug therapy*
  • Dyskinesia, Drug-Induced / pathology
  • Dyskinesia, Drug-Induced / physiopathology
  • Endocannabinoids / metabolism
  • Extracellular Signal-Regulated MAP Kinases / metabolism
  • Histones / metabolism
  • Levodopa / toxicity*
  • Male
  • Mice, Inbred C57BL
  • NF-kappa B / metabolism
  • Oxidopamine
  • PPAR gamma / metabolism
  • Parkinsonian Disorders / drug therapy
  • Parkinsonian Disorders / pathology
  • Parkinsonian Disorders / physiopathology
  • Polyunsaturated Alkamides / metabolism
  • Receptor, Cannabinoid, CB1 / metabolism
  • TRPV Cation Channels / metabolism
  • Tyrosine 3-Monooxygenase / metabolism

Substances

  • Anti-Dyskinesia Agents
  • Arachidonic Acids
  • CNR1 protein, mouse
  • Endocannabinoids
  • Histones
  • NF-kappa B
  • PPAR gamma
  • Polyunsaturated Alkamides
  • Receptor, Cannabinoid, CB1
  • TRPV Cation Channels
  • TRPV1 protein, mouse
  • Cannabidiol
  • Levodopa
  • Oxidopamine
  • Tyrosine 3-Monooxygenase
  • Ptgs2 protein, mouse
  • Cyclooxygenase 2
  • Extracellular Signal-Regulated MAP Kinases
  • capsazepine
  • Capsaicin
  • anandamide