T-Cell Abnormalities in Common Variable Immunodeficiency

J Investig Allergol Clin Immunol. 2016;26(4):233-43. doi: 10.18176/jiaci.0069. Epub 2016 Apr 15.


Common variable immunodeficiency (CVID) is the most common clinical primary immunodeficiency. It is characterized by a defect in B-cell differentiation to plasma and memory B cells. Moreover, numerous T-cell abnormalities have been reported and include decreased T-cell count and proliferative response, increased T-cell activation and apoptosis, and abnormalities in cytokine production. The aims of this review are to describe phenotypic and functional defects in T cells in CVID patients and to review the literature with respect to the effects of immunoglobulin replacement on the T-cell component in CVID patients.

Keywords: Common variable immunodeficiency; Helper T cells; Regulatory T cells; T cell.

Publication types

  • Review

MeSH terms

  • CD4-Positive T-Lymphocytes / immunology
  • Common Variable Immunodeficiency / drug therapy
  • Common Variable Immunodeficiency / immunology*
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Lymphocyte Activation
  • T-Lymphocytes / immunology*
  • T-Lymphocytes, Regulatory / immunology


  • Immunoglobulins, Intravenous