WONOEP appraisal: Molecular and cellular biomarkers for epilepsy

Epilepsia. 2016 Sep;57(9):1354-62. doi: 10.1111/epi.13460. Epub 2016 Jul 4.


Peripheral biomarkers have myriad potential uses for treatment, prediction, prognostication, and pharmacovigilance in epilepsy. To date, no single peripheral biomarker has demonstrated proven effectiveness, although multiple candidates are in development. In this review, we discuss the major areas of focus including inflammation, blood-brain barrier dysfunction, redox alterations, metabolism, hormones and growth factors.

Keywords: Blood-brain barrier; High mobility group box 1 (HMGB1); Inflammation; Insulin-like growth factor; S100B; brain derived neurotrophic factor.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomarkers / metabolism*
  • Blood-Brain Barrier / physiopathology
  • Epilepsy / genetics*
  • Epilepsy / metabolism*
  • Humans
  • Inflammation / metabolism
  • Intercellular Signaling Peptides and Proteins / genetics
  • Intercellular Signaling Peptides and Proteins / metabolism


  • Biomarkers
  • Intercellular Signaling Peptides and Proteins