Molecular Mechanism of Adult Neurogenesis and its Association with Human Brain Diseases

J Cent Nerv Syst Dis. 2016 Jun 20;8:5-11. doi: 10.4137/JCNSD.S32204. eCollection 2016.


Recent advances in neuroscience challenge the old dogma that neurogenesis occurs only during embryonic development. Mounting evidence suggests that functional neurogenesis occurs throughout adulthood. This review article discusses molecular factors that affect adult neurogenesis, including morphogens, growth factors, neurotransmitters, transcription factors, and epigenetic factors. Furthermore, we summarize and compare current evidence of associations between adult neurogenesis and human brain diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and brain tumors.

Keywords: adult neurogenesis; human brain diseases; molecular factors.

Publication types

  • Review