Correlation of IgM anti-hepatitis D virus (HDV) to HDV RNA in sera of chronic HDV

Hepatology. 1989 Jul;10(1):34-5. doi: 10.1002/hep.1840100108.


One hundred forty-four serum samples from 52 patients with chronic hepatitis D virus infection were analyzed for hepatitis D virus RNA by dot-blot hybridization using hepatitis D virus cDNA probe labeled with 32P. The results were correlated with the presence of serum IgM anti-hepatitis D virus and hepatitis D antigen in liver biopsy specimens when available. Although there was a trend of positive correlation between serum hepatitis D virus RNA and IgM anti-hepatitis D virus, no statistical significance could be found. In the serum samples with hepatitis D virus RNA, 32% were found to be negative for IgM anti-hepatitis D virus. Therefore, in chronic hepatitis D virus, absence of IgM anti-hepatitis D virus does not rule out active viral infection, as suggested by previous studies. There was a strong correlation between serum hepatitis D virus RNA and hepatic hepatitis D virus antigen. These data indicate that detection of hepatitis D virus RNA in serum samples is a reliable noninvasive marker of active viral infection.

MeSH terms

  • Antibodies, Viral / analysis*
  • Chronic Disease
  • Hepatitis D / blood
  • Hepatitis D / genetics
  • Hepatitis D / immunology*
  • Hepatitis Delta Virus / genetics
  • Hepatitis Delta Virus / immunology*
  • Humans
  • Immunoglobulin M / immunology*
  • RNA, Viral / analysis*


  • Antibodies, Viral
  • Immunoglobulin M
  • RNA, Viral