Neuroprotective Effectiveness of Intravenous Ubiquinone in Rat Model of Irreversible Cerebral Ischemia

Bull Exp Biol Med. 2016 Jun;161(2):245-7. doi: 10.1007/s10517-016-3387-1. Epub 2016 Jul 7.


The neuroprotective effect of ubiquinone (coenzyme Q10)was demonstrated on the rats model of ischemic stroke provoked by persistent 24-h occlusion of the middle cerebral artery. Coenzyme Q10 (30 mg/kg) was injected intravenously in 60 min after artery occlusion. Ubiquinone crossed the blood-brain barrier, accumulated in the brain, and produced a neuroprotective effect: it alleviated ischemia-induced neurological deficit and reduced the size of necrotic zone by 49% in comparison with rats receiving physiological saline.

Keywords: antioxidant; coenzyme Q 10 (ubiquinone); ischemic stroke; neuroprotection.

MeSH terms

  • Animals
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Free Radical Scavengers / administration & dosage*
  • Infarction, Middle Cerebral Artery / drug therapy*
  • Injections, Intravenous
  • Male
  • Neuroprotective Agents / administration & dosage*
  • Rats, Wistar
  • Ubiquinone / administration & dosage
  • Ubiquinone / analogs & derivatives*


  • Free Radical Scavengers
  • Neuroprotective Agents
  • Ubiquinone
  • coenzyme Q10