Intermolecular Hydropyridylation of Unactivated Alkenes

J Am Chem Soc. 2016 Jul 20;138(28):8718-21. doi: 10.1021/jacs.6b05271. Epub 2016 Jul 12.


A general method for the hydropyridylation of unactivated alkenes is described. The transformation connects metal-mediated hydrogen atom transfer to alkenes and Minisci addition reactions. The reaction proceeds under mild conditions with high site-selectivities and allows for the construction of tertiary and quaternary centers from simple alkene starting materials.

Publication types

  • Research Support, Non-U.S. Gov't