In Vivo MRI and X-Ray Bifunctional Imaging of Polymeric Composite Supplemented with GdPO4 ·H2 O Nanobundles for Tracing Bone Implant and Bone Regeneration

Jing Huang; Zhongwen Lv; Yu Wang; Zongliang Wang; Tianlin Gao; Ning Zhang; Min Guo; Haifeng Zou; Peibiao Zhang

doi:10.1002/adhm.201600249

In Vivo MRI and X-Ray Bifunctional Imaging of Polymeric Composite Supplemented with GdPO4 ·H2 O Nanobundles for Tracing Bone Implant and Bone Regeneration

Adv Healthc Mater. 2016 Sep;5(17):2182-90. doi: 10.1002/adhm.201600249. Epub 2016 Jul 6.

Authors

Jing Huang^{1

2}, Zhongwen Lv³, Yu Wang², Zongliang Wang², Tianlin Gao^{2

4}, Ning Zhang⁵, Min Guo², Haifeng Zou⁶, Peibiao Zhang⁷

Affiliations

¹ College of Chemistry, Jilin University, Changchun, 130012, P. R. China.
² Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
³ China-Japan Union Hospital, Jilin University, Changchun, 130021, P. R. China.
⁴ School of Public Health, Jilin University, Changchun, 130021, P. R. China.
⁵ Department of Foot and Ankle Surgery, The Second Hospital of Shandong University, Jinan, 250000, P. R. China.
⁶ College of Chemistry, Jilin University, Changchun, 130012, P. R. China. zouhf@jlu.edu.cn.
⁷ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China. zhangpb@ciac.ac.cn.

PMID: 27385162
DOI: 10.1002/adhm.201600249

Abstract

Homogeneous and monodisperse GdPO4 ·H2 O nanobundles are successfully synthesized via a solvothermal method. Then, GdPO4 ·H2 O are incorporated into the composite of hydroxyapatite and poly(lactic-co-glycolic acid) to obtain a biodegradable and traceable bone implant. After implanted, the GdPO4 ·H2 O/HA/PLGA implant and the newly formed bone can be easily traced and observed through the combination of magnetic resonance imaging and X-ray imaging.

Keywords: MR imaging; bone repair; gadolinium phosphate; hydroxyapatite; poly(lactic-co-glycolic acid); radiography.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Absorbable Implants*
Animals
Bone Regeneration*
Cell Line
Contrast Media* / chemistry
Contrast Media* / pharmacology
Durapatite* / chemistry
Durapatite* / pharmacology
Gadolinium* / chemistry
Gadolinium* / pharmacology
Magnetic Resonance Imaging*
Mice
Nanoparticles* / chemistry
Nanoparticles* / therapeutic use
Tomography, X-Ray Computed*

Substances

Contrast Media
Durapatite
Gadolinium