Programmed Nanoparticles for Tailoring the Detection of Inflammatory Bowel Diseases and Irritable Bowel Syndrome Disease via Breathprint

Adv Healthc Mater. 2016 Sep;5(18):2339-44. doi: 10.1002/adhm.201600588. Epub 2016 Jul 8.


Chemical sensors based on programmable molecularly modified gold nanoparticles are tailored for the detection and discrimination between the breathprint of irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD). The sensors are examined in both lab- and real-world clinical conditions. The results reveal a discriminative power accuracy of 81% between IBD and IBS and 75% between Crohn's and Colitis states.

Keywords: breathprint; diagnosis; inflammatory bowel disease; irritable bowel syndrome; nanoparticles; sensors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biosensing Techniques / methods*
  • Breath Tests / methods
  • Crohn Disease / diagnosis*
  • Crohn Disease / metabolism
  • Female
  • Gold / chemistry*
  • Humans
  • Metal Nanoparticles / chemistry*
  • Middle Aged


  • Gold