Burning Fat Fuels Leukemic Stem Cell Heterogeneity

Cell Stem Cell. 2016 Jul 7;19(1):1-2. doi: 10.1016/j.stem.2016.06.014.

Abstract

Obese leukemia patients exhibit reduced survival after chemotherapy, suggesting an important role of adipose tissue in disease progression. In this issue of Cell Stem Cell, Ye et al. (2016) reveal metabolic heterogeneity in leukemic stem cell (LSC) subpopulations and show that chemotherapy-resistant CD36+ LSCs co-opt gonadal adipose tissue to support their metabolism and survival.

Publication types

  • Comment

MeSH terms

  • Adipose Tissue / metabolism*
  • Humans
  • Leukemia, Myeloid, Acute*
  • Neoplastic Stem Cells*
  • Obesity*