Modeling Zika Virus Infection in Mice

Shannan L Rossi; Nikos Vasilakis

doi:10.1016/j.stem.2016.06.009

Modeling Zika Virus Infection in Mice

Cell Stem Cell. 2016 Jul 7;19(1):4-6. doi: 10.1016/j.stem.2016.06.009.

Authors

Shannan L Rossi¹, Nikos Vasilakis²

Affiliations

¹ Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0609, USA. Electronic address: slrossi@utmb.edu.
² Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA; Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, USA; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0609, USA. Electronic address: nivasila@utmb.edu.

PMID: 27392219
DOI: 10.1016/j.stem.2016.06.009

Abstract

Understanding the link between Zika virus (ZIKV) infection and microcephaly requires in vivo models of ZIKV infection in pregnant adults and fetuses. Three studies recently generated such mouse models of ZIKV infection, which corroborate previous in vitro evidence linking ZIKV infection and apoptosis induction in neurons and progenitors to microcephaly.

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MeSH terms

Animals
Apoptosis
Female
Fetus
Mice
Neurons
Pregnancy
Zika Virus Infection*
Zika Virus*