Effect of curcumin on circulating interleukin-6 concentrations: A systematic review and meta-analysis of randomized controlled trials

Pharmacol Res. 2016 Sep:111:394-404. doi: 10.1016/j.phrs.2016.07.004. Epub 2016 Jul 5.


The aim of this meta-analysis was to evaluate the efficacy of curcuminoids supplementation on circulating concentrations of IL-6 in randomized controlled trials (RCTs). The search included PubMed-Medline, Scopus, Web of Science and Google Scholar databases by up to November 01, 2015, to identify RCTs investigating the impact of curcuminoids on circulating IL-6 concentrations. Nine RCTs comprising 10 treatment arms were found to be eligible for the meta-analysis. There was a significant reduction of circulating IL-6 concentrations following curcuminoids supplementation (WMD: -0.60pg/mL, 95% CI: -1.06, -0.14, p=0.011). Meta-regression did not suggest any significant association between the circulating IL-6 lowering effects of curcuminoids with either dose or duration of treatment. There was a significant association between the IL-6-lowering activity of curcumin and baseline IL-6 concentration (slope: -0.51; 95% CI: -0.80, -0.23; p=0.005). This meta-analysis of RCTs suggested a significant effect of curcumin in lowering circulating IL-6 concentrations. This effect appears to be more evident in patients with higher degrees of systemic inflammation.

Keywords: Curcuma longa; Curcumin; Inflammation; Interleukin-6; Meta-analysis.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Adult
  • Aged
  • Anti-Inflammatory Agents / adverse effects
  • Anti-Inflammatory Agents / therapeutic use*
  • Biomarkers / blood
  • Curcumin / adverse effects
  • Curcumin / therapeutic use*
  • Down-Regulation
  • Female
  • Humans
  • Inflammation / blood
  • Inflammation / drug therapy*
  • Inflammation / immunology
  • Inflammation Mediators / blood*
  • Inflammation Mediators / immunology
  • Interleukin-6 / blood*
  • Interleukin-6 / immunology
  • Male
  • Middle Aged
  • Randomized Controlled Trials as Topic
  • Treatment Outcome


  • Anti-Inflammatory Agents
  • Biomarkers
  • IL6 protein, human
  • Inflammation Mediators
  • Interleukin-6
  • Curcumin