Isolation of a 2-Pyrone Compound as an Antioxidant from a Fungus and Its New Reaction Product with 1,1-Diphenyl-2-picrylhydrazyl Radical

A Hirota; A Nemoto; Y Tsuchiya; H Hojo; N Abe

doi:10.1271/bbb.63.418

Isolation of a 2-Pyrone Compound as an Antioxidant from a Fungus and Its New Reaction Product with 1,1-Diphenyl-2-picrylhydrazyl Radical

Biosci Biotechnol Biochem. 1999;63(2):418-20. doi: 10.1271/bbb.63.418.

Authors

A Hirota¹, A Nemoto¹, Y Tsuchiya¹, H Hojo¹, N Abe¹

Affiliation

¹ a Laboratory of Applied Microbiology, School of Food and Nutritional Sciences, University of Shizuoka.

PMID: 27393067
DOI: 10.1271/bbb.63.418

Abstract

The indophenol-reducing compound, 4-hydroxy-3,6-dimethyl-2H-pyrane-2-one (I), was isolated from the culture filtrate of an unidentified fungus. I also reacted with the DPPH radical to form a reaction product IV which was determined to be 1-[4-(3,4-dihydro-3,6-dimethyl-2,4-dioxo- 2H-pyran-3-yl)phenyl]-1-phenyl-2-picrylhydrazine. This is the first report describing the formation of an adduct of the DPPH radical and its scavenger.

Keywords: antioxidant; indophenol-reducing compound; radical-scavenging activity.