Understanding Hypoxic Drive and the Release of Hypoxic Vasoconstriction

Air Med J. 2016 Jul-Aug;35(4):210-1. doi: 10.1016/j.amj.2016.03.006. Epub 2016 Jun 3.

Abstract

Understanding the hypoxic drive and release of hypoxic vasoconstriction in the chronic obstructive pulmonary disease population can be somewhat confusing and misunderstood. Furthermore, the hypoxic drive theory is one in which there really is no scientific evidence to support and yet continues to prosper in every aspect of care in regard to the chronic lung patient, from prehospital all the way to intensive care unit and home care therapy. This subject review will hopefully enhance some understanding of what exactly goes on with these patients and the importance of providing oxygen when it is desperately needed.

MeSH terms

  • Apnea
  • Capnography
  • Humans
  • Hypercapnia / metabolism
  • Hypercapnia / physiopathology*
  • Hypoxia / metabolism
  • Hypoxia / physiopathology*
  • Hypoxia / therapy
  • Oxygen Inhalation Therapy
  • Pulmonary Disease, Chronic Obstructive / metabolism
  • Pulmonary Disease, Chronic Obstructive / physiopathology*
  • Pulmonary Disease, Chronic Obstructive / therapy
  • Vasoconstriction / physiology*