Can an increased cholinergic tone constitute a predictor of positive response to tiotropium in patients with moderate asthma?

Affiliations

• ¹ Division of Pneumology and Allergology, Department of Pulmonology, Haematology and Oncology, High Speciality "A. Cardarelli" Hospital, Naples, Italy; Postgraduate School of Respiratory Medicine, Department of Systems Medicine, University of Rome, "Tor Vergata", Rome, Italy. Electronic address: gennaro.liccardi@tin.it.
• ² Division of Pneumology and Allergology, Department of Pulmonology, Haematology and Oncology, High Speciality "A. Cardarelli" Hospital, Naples, Italy.
• ³ Department of Systems Medicine, University of Rome, "Tor Vergata", Rome, Italy.
• ⁴ Postgraduate School of Respiratory Medicine, Department of Systems Medicine, University of Rome, "Tor Vergata", Rome, Italy.
• ⁵ Department of Experimental Medicine, Second University of Naples, Naples, Italy.
• ⁶ Postgraduate School of Respiratory Medicine, Department of Systems Medicine, University of Rome, "Tor Vergata", Rome, Italy; Department of Systems Medicine, University of Rome, "Tor Vergata", Rome, Italy.