Isoprene and sleep

Life Sci. 1989;44(24):1877-80. doi: 10.1016/0024-3205(89)90306-8.


Isoprene is one of the main constituents of endogenous origin in exhaled human breath. The concentration of isoprene seems to vary with states of sleep and wakefulness, increasing during sleep and decreasing sharply just after awakening. Thus, isoprene may be involved in in sleep upholding.

MeSH terms

  • Acetone / metabolism
  • Breath Tests
  • Butadienes / metabolism*
  • Hemiterpenes*
  • Humans
  • Pentanes*
  • Sleep / physiology*
  • Wakefulness


  • Butadienes
  • Hemiterpenes
  • Pentanes
  • isoprene
  • Acetone