Evaluation of the adjunctive effect of platelet-rich fibrin to enamel matrix derivative in the treatment of intrabony defects. Six-month results of a randomized, split-mouth, controlled clinical study

J Clin Periodontol. 2016 Nov;43(11):955-964. doi: 10.1111/jcpe.12598. Epub 2016 Sep 13.


Aim: This study aimed to compare the results obtained with enamel matrix derivative (EMD) and EMD + platelet-rich fibrin (PRF) in the treatment of intrabony defects (IBDs) in chronic periodontitis patients.

Materials and methods: Using a split-mouth design, 28 paired IBDs were randomly treated either with EMD or with EMD + PRF. Clinical and radiographic measurements including clinical attachment level (CAL), probing depth (PD), gingival recession (GR), defect depth (DD), defect width (DW) and defect angle (DA) were recorded at baseline (BL) and at six months following therapy.

Results: BL clinical and radiographic measurements were similar for EMD and EMD + PRF groups. Although postsurgical measurements revealed significant reduction for PD and CAL in both groups, no intergroup difference was detected. When EMD and EMD + PRF groups were compared, defect fill was not also statistically different.

Conclusions: Both therapies resulted in significant clinical improvement in IBD treatment. Addition of PRF did not improve the clinical and radiographic outcomes.

Keywords: emdogain; intrabony defect; periodontal regeneration; platelet-rich fibrin; treatment.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Alveolar Bone Loss
  • Dental Enamel Proteins
  • Dental Enamel*
  • Follow-Up Studies
  • Humans
  • Periodontal Attachment Loss
  • Periodontal Pocket
  • Platelet-Rich Fibrin


  • Dental Enamel Proteins