Expression of a large family of POU-domain regulatory genes in mammalian brain development

Nature. 1989 Jul 6;340(6228):35-41. doi: 10.1038/340035a0.


A novel region referred to as the POU-domain is present in two tissue-specific transcription factors, Pit-1 and Oct-2, that activate expression of genes specifying pituitary and lymphocyte phenotypes. We report the identification of multiple new members of a large family of POU-domain genes expressed in adult brain, and document that all the known mammalian POU-domain genes, including Pit-1 and Oct-2, are expressed widely in the developing nervous system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Brain / embryology*
  • Gene Expression Regulation*
  • Genes*
  • Genes, Regulator*
  • Humans
  • Molecular Sequence Data
  • Rats
  • Sequence Homology, Nucleic Acid
  • Spinal Cord / embryology
  • Transcription Factors / genetics


  • Transcription Factors